Khmer palm-leaf manuscripts are a distinctive component of the cultural heritage of the Khmer community in A Giang Province, Vietnam. They preserve Buddhist scriptures together with historical records, traditional knowledge, and cultural values that have been transmitted through generations. This paper examines the place of these manuscripts within the cultural heritage system and considers their potential for sustainable development. The research draws on historical sources, fieldwork, document analysis, and interviews conducted at Khmer Theravada Buddhist temples in Tri Tôn District and Tịnh Biên Town. The results show that palm-leaf manuscripts exist in close association with temples, Buddhist education, traditional festivals, and the knowledge and skills of manuscript production. These relationships have enabled the continuity of the manuscripts as a living heritage. At the same time, the study identifies several threats, including the decline of skilled artisans, the shortage of suitable palm leaves, inadequate conservation conditions, and the limited integration of this heritage into cultural tourism. The paper argues that Khmer palm-leaf manuscripts should be understood and managed as part of an interconnected cultural heritage system. Such an approach provides a stronger basis for heritage preservation, the transmission of traditional knowledge, and sustainable cultural development in A Giang Province.